全文获取类型
收费全文 | 11534篇 |
免费 | 625篇 |
国内免费 | 228篇 |
专业分类
耳鼻咽喉 | 56篇 |
儿科学 | 347篇 |
妇产科学 | 62篇 |
基础医学 | 1726篇 |
口腔科学 | 28篇 |
临床医学 | 1192篇 |
内科学 | 3709篇 |
皮肤病学 | 49篇 |
神经病学 | 209篇 |
特种医学 | 262篇 |
外科学 | 1014篇 |
综合类 | 1121篇 |
现状与发展 | 3篇 |
预防医学 | 1232篇 |
眼科学 | 16篇 |
药学 | 552篇 |
1篇 | |
中国医学 | 67篇 |
肿瘤学 | 741篇 |
出版年
2023年 | 553篇 |
2022年 | 726篇 |
2021年 | 846篇 |
2020年 | 1086篇 |
2019年 | 518篇 |
2018年 | 501篇 |
2017年 | 476篇 |
2016年 | 450篇 |
2015年 | 497篇 |
2014年 | 899篇 |
2013年 | 696篇 |
2012年 | 593篇 |
2011年 | 606篇 |
2010年 | 586篇 |
2009年 | 577篇 |
2008年 | 393篇 |
2007年 | 392篇 |
2006年 | 334篇 |
2005年 | 260篇 |
2004年 | 195篇 |
2003年 | 176篇 |
2002年 | 164篇 |
2001年 | 183篇 |
2000年 | 89篇 |
1999年 | 120篇 |
1998年 | 89篇 |
1997年 | 18篇 |
1996年 | 30篇 |
1995年 | 18篇 |
1994年 | 18篇 |
1993年 | 10篇 |
1992年 | 40篇 |
1991年 | 31篇 |
1990年 | 36篇 |
1989年 | 25篇 |
1988年 | 18篇 |
1987年 | 13篇 |
1986年 | 6篇 |
1985年 | 8篇 |
1984年 | 8篇 |
1982年 | 6篇 |
1981年 | 8篇 |
1978年 | 7篇 |
1977年 | 11篇 |
1976年 | 8篇 |
1975年 | 6篇 |
1974年 | 5篇 |
1973年 | 11篇 |
1972年 | 8篇 |
1968年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Clinical Effectiveness of Erlova in EGFR-Mutated Non-Small Cell Lung Cancer: An Affordable Price with Clinical Benefit 下载免费PDF全文
Sharareh SeifiBabak SalimiZahra Esfahani-MonfaredRamin RadmaneshSaeed YaghoubifardSara TalebianpourAdnan Khosravi 《Asian Pacific journal of cancer prevention》2022,23(4):1155-1158
Background: Thyrosin kinase inhibitors (TKIs) is approved for the first line treatment of non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation. This study performed to assess clinical effectiveness and safety of Erlova (generic form of Erlotinib). Methods: Somatic mutations of EGFR gene were studied in tumor tissue by polymerase chain reaction (PCR) and bi-directional sequencing in 513 chemonaive and histologically verified lung adenocarcinoma Iranian patients. Patients with EGFR mutation received Erlova at 150 mg/day as first line treatment. Primary endpoint was progression free survival (PFS). Results: About 21% (n=109) cases had EGFR mutation. Most EGFR mutations were occurred at exon 19. Among them, sixty nine patients treated with Erlova. Median PFS was 11.4 months and objective response rate (ORR) was about 88%. Most frequent treatment related adverse events was skin rash. Conclusion: Our findings showed Erlova had remarkable effectiveness. In mutation-positive patients with EGFR, Erlova can be used safely instead of other tyrosine-kinase inhibitors. 相似文献
5.
6.
7.
《Journal of infection and chemotherapy》2022,28(12):1672-1676
Mycoplasma hominis is a commensal pathogen normally found in urogenital tract of humans and has been associated with a wide variety of extra-genitourinary infections, such as mediastinitis, bacteremia, and septic arthritis, particularly in immunocompromised patients. Here, we present a case of a 48-year-old male, who had been treated with fingolimod for relapsing multiple sclerosis and presented with fever and right-sided hip pain following total hip arthroplasty. CT scan revealed localized fluid collection in the right quadriceps femoris muscle adjacent to the joint cavity of right hip. The percutaneously aspirated fluid grew M. hominis, which was also isolated from blood culture. With diagnosis of periprosthetic joint infection, the patient underwent surgical debridement with retained prosthesis and was treated with antimicrobial agents. Infected granulation tissues excised from the hip was observed under an electron microscope, which revealed electron-dense rounded structures contained in neutrophils, consistent with Mycoplasma particles. Fingolimod, an immunomodulatory drug that acts on the sphingosine-1-phosphate receptor and prevents the egress of lymphocytes from lymph nodes, might increase host susceptibility to a systemic M. hominis infection. 相似文献
8.
《Journal of infection and chemotherapy》2022,28(2):352-355
IntroductionMonoclonal antibody therapy has been reported to be highly effective for preventing hospitalisation and severe cases in patients with Coronavirus Disease 2019 (COVID-19). However, since the drug is not readily available, it is important to rapidly and appropriately identify high-risk patients who can benefit most from therapy. Therefore, we designed a risk scoring system to identify at-risk COVID-19 patients in our region during the largest surge of COVID-19, from July to September 2021.MethodsAccording to the risk scores, confirmed COVID-19 patients were introduced to receive REGN-CoV-2 to our hospital by regional health centre from 18th August (Term 3). The primary outcome was the comparison of the number of hospitalisation and severe condition with other periods, the 4th wave (Term 1) and the early part of the 5th wave (Term 2) in Japan.ResultsDuring Term 3, 115 patients were stratified with the scoring system and administered REGN-COV-2. The number of hospitalisation vs severe cases were 60 (5.2%) vs 14 (1.2%), 8 (1.5%) vs 3 (0.6%) and 21 (1.2%) vs 2 (0.1%), in term 1, 2 and 3, respectively. Among those aged <60 years, compared with term 1, the relative risk of hospitalisation and severe condition were 0.25 (95% CI: 0.12–0.53) and 0.10 (95% CI: 0.01–0.80), respectively, in term 3. Drug adverse events were fever (3: 2.6%), headache (1: 0.9%) and neck rash (1: 0.9%), all events were resolved within 24 h wth no serious adverse event.ConclusionsThe administration of monoclonal antibody therapy using a risk scoring system significantly reduced the number of hospitalisation and disease severity of COVID-19 without any serious adverse events and avoided regional medical collapse. 相似文献
9.
10.
《Journal of cystic fibrosis》2022,21(5):821-829
OligoG has previously shown potentiation of aztreonam against Burkholderia cepacia complex (Bcc) through biofilm disruption. A randomized, double-blind, placebo-controlled cross-over design was used to evaluate safety and efficacy of inhaled OligoG as a therapy for Bcc-infected CF patients taking aztreonam. Subjects received OligoG (1050 mg daily) or matching placebo for 28-days. Of 14 subjects completing the study, 8 showed a mean decrease in total bacterial CFU's (0.82 log10) after OligoG treatment. There was a reduction in mean Bcc CFU's (2.19 log10) after OligoG treatment but this was not statistically significant. Rheology analysis showed improvements in phase-angle after OligoG, but there was no statistically significant improvement in lung function parameters. Six out of 12 QoL summary scores showed relative improvement after OligoG treatment compared to placebo. There was a favourable safety profile for OligoG. Potential for reducing Bcc warrants further investigation of OligoG for the treatment of infection in CF. 相似文献